Sirtuin Genes: Your Skin’s Genetic Code for Youth

C’LIFE Science Blog – C’LOPIA EPIGEN Series

July 2025

🧠 Aging isn’t fate — it’s silence in your genes.

Sirtuins are the memory of youth inside your cells.

They regulate DNA repair, collagen production, inflammation, and mitochondrial health. But they need a spark to work: NAD⁺.

🔬 Why Are Sirtuins So Important?

• SIRT1 → Boosts collagen synthesis

• SIRT3 → Protects mitochondria from UV damage

• SIRT6 → Supports DNA repair and telomere health

In the skin, they slow aging, promote regeneration, and strengthen the barrier.

🔗 Reference: Haigis & Sinclair, Cell, 2010

https://doi.org/10.1016/j.cell.2010.03.007

🌿 Natural Sirtuin Activators:

✅ 1. Resveratrol

Found in grape skins. Activates SIRT1.

✅ 2. Curcumin

From turmeric. Boosts NAD⁺ levels and stimulates sirtuins.

✅ 3. Fisetin

Found in strawberries. Acts as a senolytic — clears old cells.

🔗 PMC3173265

✅ 4. Quercetin

In apples, onions, grape skin. SIRT1 activator.

🔗 Biochem J, 2006

✅ 5. Pterostilbene

From blueberries. Higher bioavailability than resveratrol.

🔗 Oxid Med Cell Longev, 2013

✅ 6. Apigenin

In parsley, celery, chamomile. Supports SIRT6.

🔗 Toxicol Appl Pharmacol, 2010

✅ 7. Kaempferol

Found in broccoli and kale. Activates sirtuin pathways.

🔗 Nutrients, 2018

💡 Final Thought:

Sirtuins are not just anti-aging molecules.

They are your genetic software for youth.

C’LOPIA EPIGEN embraces this molecular truth and brings a science-led, inside-out approach to longevity and skin health.

True care starts at the genetic level.